The main aim of this study was to investigate a selection of commonly used performance indicators (PIs) that have been reported to be sensitive to distraction and workload. More specifically, the PIs were tested for their ability to differentiate between task modalities (visual, cognitive and haptic) and task difficulty (easy, medium and hard). It was investigated whether possible differences were constant across two traffic situations (with/without lead vehicle) and two driving simulators. The experiment was conducted in the VTI Driving Simulator III, an advanced moving-base simulator, and in the Volvo Car Corporation driving simulator, an advanced fixed-base simulator. Both simulators were equipped with Smart Eye Pro eye tracking systems. A visual, a cognitive and a haptic secondary task were chosen to test the ability of the PIs to distinguish between the tasks’ loading on different modalities. Some of the main results from the study were: