here have been efforts in Sweden to convert and transform single carriageway roads into collision-free roads. The structural design and cost-effectiveness of these roads have mainly been performed using empirically derived pavement design methods. Currently, the Swedish Transport Administration (STA) is financing a project aimed at developing and implementing a mechanistic-empirical (M-E) pavement design approach for Swedish conditions. This is expected to impact long-term pavement performance and subsequently, the total life cycle cost (LCC) of projects. This paper examines, through design alternatives, the impact of a pavement design method on the total LCC of a road project. This is achieved by designing and analyzing an actual flexible pavement structure using two empirical pavement design methods and one M-E pavement design method. A life cycle cost analysis (LCCA) was employed to estimate future maintenance and rehabilitation (M&R) and road user costs, as well as initial construction and end-of-life costs. The cost estimation was conducted considering various combinations of interest and inflation rates that are expected to reflect current and future cost trends. The analyses have shown that the M-E pavement design approach delivered the least LCC, but this LCC is observed to vary considerably depending on the inflation and interest rates employed.