Recycled and waste materials from four different sources were investigated as alternatives for crushed rock aggregates in pavement constructions. Two of the materials were coarse fractions of the bottom ash from two incineration plants. The other two materials were crushed concrete from demolished constructions and reclaimed asphalt from road scalpings. Full-scale accelerated tests were conducted on test road-sections constructed with these materials, employing a heavy vehicle simulator (HVS). The materials were also tested in the laboratory e.g., by means of repeated load triaxial (RLT) tests. In both cases, results indicated that the crushed concrete performed the best, followed by the two bottom ash materials and then the reclaimed asphalt. The results from the RLT tests were used to evaluate the model parameters required for simulating the performances of the test-road sections in HVS tests, adopting a mechanistic-empirical pavement analysis tool ERAPave. With this method, good agreements between the measurements and simulations were obtained. Hence, this approach forms the basis for designing pavement sections using these alternative materials for different traffic loading and climatic conditions. With further testing and modelling, it will be possible to create guidelines and design tables for pavement constructions with alternative materials.