This paper presents a new conceptual framework, and stepwise approach to populate it, for informing countermeasure development to support fitness-to-drive for professional drivers. Professional drivers are vital to the transport network; however, the job is demanding and drivers are vulnerable to impairments which may impact safe driving. Countermeasures are any action or activity that mitigates the impact or frequency of occurrence of driver impairment. The framework proposes countermeasures to be delivered across three time points: Operational (during shift), Tactical (immediately after shift) and Strategic (outside of on-shift) and at multiple system levels, e.g., driver, manager, enforcement etc. The framework was successfully pilot tested with three different professional driver use cases: autonomous shuttles, taxi, and garbage truck drivers. This structured approach to countermeasure design offers potential to improve driver health and enhance road safety. The work was conducted within , an EU project, grant agreement number .