Usually, aggregates used for asphalt mixtures consist mainly of natural aggregates. Sometimes the natural aggregates are substituted with limited amounts of industrial and construction wastes. The current paper deals with evaluating the mechanical performance of new developed hot asphalt mixtures made of up to 98% industrial and construction by products. In this project, different types of industrial by-products, namely, RAP, foundry sand, and steel slag in addition to biobased rejuvenators have been used to find the composition of the best asphalt mixtures made mainly of wastes that can substitute the asphalt mixtures made of natural aggregates. Fourteen selected asphalt mixtures have been evaluated using the circular road simulator test at VTI. The CRS testing program has been set up to allow different measurements, e.g. surface deterioration and wear, friction, and visual inspection. The test results demonstrated that it is possible to obtain paving mixtures with high content of recycled materials.