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Growth factors and neurotrophins in patients with stress-related exhaustion disorder
Swedish National Road and Transport Research Institute, Traffic and road users, Human Factors in the Transport System.
Göteborgs Universitet.
Göteborgs Universitet.
The Institute of Stress Medicine, Region Västra Götaland.
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2019 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 109, article id 104415Article in journal (Refereed) Published
Abstract [en]

Growth factors, such as vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF), and neurotrophic factors, including brain-derived neurotophic factor (BDNF), have attracted attention in studies of the biological effects of long-term stress exposure due to their neuroprotective roles. This study investigated whether circulating levels of EGF, VEGF and BDNF were altered in individuals with stress-related exhaustion disorder. Forty patients diagnosed with exhaustion disorder and 40 healthy subjects (50% women) provided fasting blood samples for analysis of EGF, VEGF, and BDNF in plasma. We found significantly lower levels of EGF, VEGF, and BDNF in patients with ED compared to healthy controls. This pattern was seen in both male and female patients. Given the important roles of BDNF and VEGF for brain plasticity and neurogenesis, decreased levels after long-term stress exposure could indicate increased risk of neuronal damage and cognitive impairments in this patient group.

Place, publisher, year, edition, pages
Elsevier Ltd , 2019. Vol. 109, article id 104415
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Neurology
Identifiers
URN: urn:nbn:se:vti:diva-14163DOI: 10.1016/j.psyneuen.2019.104415Scopus ID: 2-s2.0-85071301349OAI: oai:DiVA.org:vti-14163DiVA, id: diva2:1356279
Available from: 2019-10-01 Created: 2019-10-01 Last updated: 2019-10-01Bibliographically approved

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Sjörs Dahlman, Anna

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CiteExportLink to record
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  • apa
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  • nn-NB
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  • Other locale
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Output format
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