Traffic accidents between vehicles and vulnerable road users, and the senior part of the population particularly, is a traffic safety problem that must be addressed continuously. A safe driving guidance system such as an intelligent speed adaptation system that suppress the speed to prevent and mitigate accidents is an important measure that can address this traffic safety problem. In specific, the accidents targeted in this paper are those that appear in intersections. An intelligent speed adaptation system with acoustic and graphical information that is adapted to the driver’s characteristics to increase the compliance with the guidance provided by the system is developed. Two driving simulator studies were conducted as part of the development procedure. The results of these experiments indicated that a speed restraining effect could be determined of the system and different human-machine-interfaces were compared. The safe driving guidance system was also optimized to driver characteristics and a target value was presented with an optimal value. Implications for system design and human-machine-interaction is discussed.